• Home
  • About
    • Senior Management
    • Board of Directors
    • Scientific Advisory Board
  • Products
    • TNX-201 (oral enteric coated imatinib)
    • TNX-103 (oral levosimendan)
  • Education Center
    • Featured Articles
    • Education Categories
    • Viewpoints
  • Investors/Media
  • Contact
Contact Icon Contact Icon Contact Icon
  • Home
  • About
    • Senior Management
    • Board of Directors
    • Scientific Advisory Board
  • Products
    • TNX-201 (oral enteric coated imatinib)
    • TNX-103 (oral levosimendan)
  • Education Center
    • Featured Articles
    • Education Categories
    • Viewpoints
  • Investors/Media
  • Contact
  • Home
  • About
    • Senior Management
    • Board of Directors
    • Scientific Advisory Board
  • Products
    • TNX-201 (oral enteric coated imatinib)
    • TNX-103 (oral levosimendan)
  • Education Center
    • Featured Articles
    • Education Categories
    • Viewpoints
  • Investors/Media
  • Contact

Education Center

Scientific Resources & Research Materials

IMPORTANT NOTICE

When accessing any publication you will leave this Site and enter the NCBI Website, which is subject to NCBI Disclaimer and Copyright Notice.

All publications are links provided for your convenience. We have no control over the other site’s content.

Search Publications

FEATURED ARTICLES

Venous Tone and Stressed Blood Volume in Heart Failure

This soon-to-be classic review offers a very understandable explanation about the importance of venous return in normal physiology and heart failure. While preload is an old concept, it has never been appreciated to have a major impact in managing heart failure patients until now. The studies referenced in this paper predict novel treatments of heart failure based on the concepts of stressed and unstressed blood volume. Levosimendan is the first drug to ever result in clinical improvement based on these concepts.

Citation
Fudim M, Kaye DM, Borlaug BA, Shah SJ, Rich S, Kapur NK, Costanzo MR, Brener MI, Sunagawa K, Burkhoff D. Venous Tone and Stressed Blood Volume in Heart Failure: JACC Review Topic of the Week. J Am Coll Cardiol. 2022 May 10;79(18):1858-1869.
Source: https://pubmed.ncbi.nlm.nih.gov/35512865/

Association Of Borderline Pulmonary Hypertension With Mortality And Hospitalization In A Large Patient Cohort: Insights From The Veterans Affairs Clinical Assessment, Reporting, And Tracking Program

This is a retrospective study of over 20,000 patients with pulmonary hypertension confirmed by cardiac catheterization, from any cause who were followed for clinical outcomes. Like other studies it confirmed the increasing mortality beginning at the mildest levels of increased pulmonary artery pressure. The case can be made for screening programs to detect early disease to initiate treatments.

Citation
Maron BA, Hess E, Maddox TM, Opotowsky AR, Tedford RJ, Lahm T, Joynt KE, Kass DJ, Stephens T, Stanislawski MA, Swenson ER, Goldstein RH, Leopold JA, Zamanian RT, Elwing JM, Plomondon ME, Grunwald GK, Barón AE, Rumsfeld JS, Choudhary G. Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program. Circulation. 2016 Mar 29;133(13):1240-8
Source: https://pubmed.ncbi.nlm.nih.gov/26873944/

A Global View of Pulmonary Hypertension

This is one of the more in-depth reviews of the global burden of pulmonary hypertension. They estimate a prevalence of 1% of the world population having pulmonary hypertension from any cause. They also estimate that the large majority of these patients (80%) live in developing countries, which emphasizes the challenge for both preventive and treatment strategies that will be affordable and accessible.

Citation
Hoeper MM, Humbert M, Souza R, Idrees M, Kawut SM, Sliwa-Hahnle K, Jing ZC, Gibbs JS. A global view of pulmonary hypertension. Lancet Respir Med. 2016 Apr;4(4):306-22.
Source: https://pubmed.ncbi.nlm.nih.gov/26975810/

Understanding the Pathobiology of Pulmonary Hypertension Due to Left Heart Disease

This is an in depth authoritative review of the field of pulmonary hypertension due to left heart disease. Written by one of the most renown thought leaders, it covers all facets of basic and clinical science, with insights into potential effective therapies. A must read for anyone who is involved with translational of clinical investigations in this area.

Citation
Huston JH, Shah SJ. Understanding the Pathobiology of Pulmonary Hypertension Due to Left Heart Disease. Circ Res. 2022 Apr 29;130(9):1382-1403.
Source: https://pubmed.ncbi.nlm.nih.gov/35482841/

EDUCATION CATEGORIES

CLICK BELOW TO BROWSE CATEGORIES

WHO Group 1 : PAH

REVIEWS
PATHOLOGY
PATHOBIOLOGY
TREATMENTS
Presentations

WHO Group 2 : PH-LD

REVIEWS
PATHOLOGY
PATHOBIOLOGY
TREATMENTS
Presentations

Clinical Trial Science

ENRICHMENT
STRATEGIES
NOVEL DESIGNS
ENDPOINTS
PRECISION MEDICINE

PH: Global Health Issues

GLOBAL BURDEN
OF DISEASE
PREVALENCE
STUDIES
SCREENING
STRATEGIES

TENAX VIEWPOINTS

PREFERRED APPROACH

FOR IMATINIB

IMATINIB

AS DISEASE MODIFYING THERAPY

PH-HfPEF

DISTINCTIVE FEATURES

IMATINIB

AS ORAL
TREATMENT

  • Products
    • TNX-201 (oral enteric coated imatinib)
    • TNX-103 (oral levosimendan)
  • Education Center
    • Featured Articles
    • Education Categories
    • Viewpoints
  • Contact
    • Email

Tenax Therapeutics

Specialty pharmaceutical company focused on identifying and developing therapeutics that address cardio-pulmonary diseases with high unmet medical need, with an initial therapeutic focus on pulmonary hypertension.

Contact Icon Contact Icon Contact Icon

© Copyright 2022 Tenax Therapeutics. All Rights Reserved.
Site created by Top Shelf Design

  • Privacy Policy
  • Terms of Service